R. Mehdiyev, F. Huseynov, A. Hajiyev. Main Medical Department of Ministry of Justice, Baku, Azerbaijan.
Setting: Specialized Treatment Institution, Ministry of Justice, Azerbaijan.
Objective: To examine interim outcomes of treatment of the patients, who received Cfz and Amx/CIv in complex treatment with 2nd line drugs.
Methods: We observed the results of culture conversion of the patients who received Cfz and Amx/CIv among other 2nd line ТВ drugs. These drugs were prescribed to patients whose DST showed resistance to some other 2nd line drugs. Sputum smear, culture and DST were performed on all patients at the beginning of treatment and thereafter according to treatment protocols. 15 patients have received both medications (2-8 months), 10 only Cfz (1-14 months), 17 patients only Amx/CIv (1-8 months).
Results: See Table.
Treatment
regimen with
|
Patients
N
|
Patients whose culture converted, clinical and radiological improvements occurred * (%) | Patients whose culture became positive again after stopping drug intake n (%) |
Cfz + Amx/CIv
|
15
|
12(80)
|
4 (33)
|
Cfz | 10 | 8 (80) | 4 (50) |
Amx/CIv | 17 | 11 (65) | 6 (55) |
Conclusion: Despite the fact that a combination of Cfz and Amx/CIv were used for a short period for
DR-ТВ patients, the obvious positive effect of treatment is possible to observe. Deterioration of bacteriological, clinical and radiological condition after stopping the drug intake proves the effectiveness of this combination one more time. Longer and more in depth analysis should be carried out. However, in our case it was impossible because the supply of these two drugs was stopped and future availability is uncertain.